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患有基尿症的患者的口腔微生物群:一个基于国家的横截面研究

Memduh Bingöl¹, Alessio Cardilli^2,3, Anne Carolin Bingöl⁴

¹Department of Periodontology, Oral Medicine and Oral Surgery, Institute for Dental and Craniofacial Sciences, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Journal of clinical periodontology

|May 15, 2024

概括

低蛋白饮食的基尿症 (PKU) 患者表现为口腔微生物多样性减少和牙健康恶化. 他们的饮食影响口腔微生物群,可能增加炎症和口腔疾病风险.

科学领域:

口腔微生物学口腔微生物学
饮食科学饮食科学
免疫学免疫学免疫学

背景情况:

口腔微环境是由饮食塑造的,并影响免疫平衡.
基尿症 (PKU) 患者坚持终身低蛋白饮食,为研究饮食与微生物群相互作用提供了一个独特的模型.
PKU与更高的口腔疾病发病率有关,如牙周炎.

研究的目的:

调查PKU患者的饮食,口腔微生物群组成和牙健康之间的关系.
为了比较PKU患者的口腔微生物概况与年龄匹配的对照.

主要方法:

在唾液和下斑块样本上进行了16S rDNA测序.
该研究包括109名PKU患者和114名对照患者 (年龄在6-68岁之间).
口腔微生物组成与各种牙健康指数相关.

主要成果:

与对照组相比,PKU患者的牙健康状况较差,口腔微生物多样性减少.
在PKU患者中观察到特定细菌种群,特别是Actinobacteriota的丰度存在显著差异.
增加的α多样性,特点为Tannerella属,与PKU患者的牙周健康状况不佳有关.

结论:

在PKU中限制饮食可能会破坏口腔微生物和免疫平衡,导致炎症和口腔疾病.
患有口腔炎的PKU患者的α多样性增加表明微生物的扩大.
临床上正常的牙健康状况的PKU患者的微生物特征与通常在牙周炎中观察到的不同.

关键词:

16s rDNA 测序的测序方法牙周炎是指牙周炎的一种疾病.基尿症是什么? 基尿症是什么?这是唾液,唾液.牙下面的斑块可能会出现.

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