环境纳米颗粒对神经退行症的影响
Cristina Hermosillo-Abundis1, Miguel A Méndez-Rojas1, Oscar Arias-Carrión2
1Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, Puebla City, Mexico.
Journal of neuroscience research
|May 15, 2024
概括
纳米粒子提供医疗益处,但具有神经毒性风险. 了解纳米粒子如何到达大脑对于公共卫生和开发安全的治疗策略至关重要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生物医学工程 生物医学工程
背景情况:
- 纳米粒子广泛来自自然和人为来源.
- 它们具有双重潜力:有益的生物医学应用和健康危害.
- 意外暴露引起了公众健康的担忧,特别是关于神经毒性.
研究的目的:
- 为了回顾纳米颗粒的矛盾性质.
- 探索它们在医疗保健中的应用,特别是通过血脑屏障传递药物.
- 检查潜在的神经毒性后果和通往大脑的途径.
主要方法:
- 关于纳米粒子暴露和神经毒性的文献综述.
- 对纳米粒子转移到大脑的途径的分析.
- 检查证据,将纳米粒子暴露与神经退行性疾病联系起来.
主要成果:
- 纳米粒子可以穿越血脑屏障.
- 有证据表明,纳米粒子暴露与神经退行性疾病之间存在相关性.
- 神经毒性的机制需要进一步阐明.
结论:
- 为了了解纳米粒子神经毒性,全面的研究是必不可少的.
- 需要战略干预和保护性政策.
- 为了安全利用纳米粒子,平衡治疗效益与健康风险至关重要.
相关概念视频
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Drugs Affecting Neurotransmitter Synthesis
1.4K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.4K
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K


