使用阿尔特普拉斯清除腹膜透析导管闭塞
1Department of Pharmacy, Augusta University Medical Center, Augusta, Georgia.
Hospital pharmacy
|May 15, 2024
概括
阿尔特普拉斯有效清除腹膜透析 (PD) 导管中的纤维素封闭,可能减少对外科手术的需要. 本综述检查了阿尔特普拉斯在治疗PD导管功能障碍方面的证据.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 血管外科 血管外科
背景情况:
- 腹腔透析 (PD) 导管并发症导致20%的PD转移到血液透析.
- 来自纤维素沉积物的外流阻塞是一种常见的PD导管并发症.
- 阿尔特普拉斯用于耐火性纤维素封闭,但证据有限.
研究的目的:
- 审查现有的关于用阿尔特来治疗纤维素诱导的PD导管闭塞的文献.
- 评估阿尔特在治疗PD导管功能障碍方面的疗效和安全性.
主要方法:
- 使用MEDLINE和引用跟踪进行了全面的文献搜索.
- 搜索术语包括"alteplase"",腹膜透析导管"",闭塞"",纤维素"和"组织等离子素激活剂".
- 包括的研究包括1个试点研究,3个案例系列和2个案例报告.
主要成果:
- 在大多数报告的病例中,alteplase成功清除了PD导管封闭.
- 不成功的治疗往往揭示了可以通过手术纠正的或机械原因.
- 阿尔特普拉斯在解决与纤维素相关的PD导管阻塞方面表现出高的成功率.
结论:
- 阿尔特普拉斯是一种切实可行的替代手术导管切除纤维素闭塞的替代方案.
- 它似乎是安全的,并可能减少手术纠正的必要性.
- 进一步的研究可能会巩固阿尔特普拉斯在PD导管管理中的作用.
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