患者控制的止痛药的演变:从静脉注射到舌下治疗
Julie Golembiewski1, Joseph Dasta2, Pamela P Palmer3
1Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, Illinois.
Hospital pharmacy
|May 15, 2024
概括
苏芬坦尼尔语言下药片系统 (SSTS) 在手术后提供快速,有效的急性疼痛缓解,性能优于IV PCA吗啡. 这种非侵入性方法提高了患者的满意度,并可能降低与IVPCA问题相关的医院费用.
科学领域:
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
- 卫生经济学 卫生经济学
背景情况:
- 静脉注射患者控制止痛 (IV PCA) 对于术后疼痛至关重要,但存在诸如错误,感染风险和缓慢作用的吗啡等缺点.
- 吗啡的缓慢发作可能导致不充分的疼痛控制和阿片类药物剂量堆叠.
- 目前的IV PCA方法有助于整体医疗保健成本.
研究的目的:
- 评估新型苏芬坦尼尔舌下药片系统 (SSTS) 作为一种非侵入性患者控制止痛 (PCA) 替代方案.
- 为了比较SSTS与IVPCA吗啡的疗效,安全性和患者满意度.
- 通过减轻IVPCA相关问题来评估SSTS的潜在成本效益.
主要方法:
- 第三期临床试验涉及接受重大开放腹部和骨科手术的患者.
- 苏芬坦尼尔通过舌下药片系统 (SSTS) 给药,隔离时间为20分钟.
- 在SSTS和IVPCA吗啡之间对止痛的开始,剂量间隔和患者/护士满意度的比较.
主要成果:
- 在手术后的患者中,SSTS迅速实现了疼痛缓解.
- 对于SSTS的平均剂量间隔比IVPCA吗啡 (81分钟 vs. 47分钟) 长得多.
- 报告显示,患者和护士对使用SSTS的满意度很高.
结论:
- 苏芬坦尼尔语言下药片系统 (SSTS) 在医院环境中提供快速有效的按需急性疼痛缓解.
- SSTS显示出克服IVPCA局限性的潜力,包括改善疼痛管理和降低并发症风险.
- SSTS的非侵入性和有效性表明,它可能会降低与IVPCA相关问题的医院费用,提高患者的护理.
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