治疗前的血栓细胞瘤和卵巢癌存活率:一个元分析
Vasilios Pergialiotis1, Lito Vogiatzi Vokotopoulou1, Dimitrios-Efthymios Vlachos1
1First Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
概括
在卵巢癌患者中,治疗前的血栓细胞瘤或高血小板计数与晚期疾病,复发风险增加和死亡率增加有关. 这一发现突显了血栓细胞瘤作为卵巢癌管理中的潜在预后指标.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 血栓细胞症 (血小板数升高) 与各种癌症的较差结果有关.
- 了解其在卵巢癌中的作用对于预后和治疗策略至关重要.
研究的目的:
- 为了研究治疗前的血栓细胞形成对卵巢癌患者的生存的影响.
- 评估血栓细胞瘤与疾病进展,复发和死亡率之间的关联.
主要方法:
- 在Medline,Scopus,Clinicaltrials.gov,CENTRAL和谷歌学者的系统文献综述.
- 包括的研究比较了卵巢癌患者的生存结果,包括治疗前的血栓细胞瘤和没有血栓细胞瘤.
- 分析了包括5414名患者在内的14篇文章.
主要成果:
- 在治疗前的血栓细胞瘤在晚期卵巢癌中更为常见.
- 血栓细胞瘤与较低的最佳外科解压率相关.
- 患有血栓细胞瘤的患者出现复发 (HR 2.01) 和死亡 (HR 2.29) 的可能性显著增加.
- 深静脉血栓发生率在各组之间是相似的.
结论:
- 治疗前的血栓细胞瘤是卵巢癌复发和死亡风险增加的重要指标.
- 它可以预测晚期疾病和不理想的外科手术结果.
- 需要进一步的研究来探索其与抗性和向治疗反应的联系.
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