单核酸多态对结合冠状动脉疾病的抑郁症的影响:系统性审查和元分析
Jing Zhang1, Lu Gao1, Guan Lin Yang1
1Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Frontiers in endocrinology
|May 15, 2024
概括
5-HTTLPR和BDNF基因中的单核酸多态 (SNP) 与患抑郁症和冠心病 (CHD) 的风险增加有关. 这些遗传变异可能成为这种并发症的重要生物标志物.
科学领域:
- 遗传学 是一个遗传学.
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
背景情况:
- 抑郁症和冠心病 (CHD) 具有共同的风险机制.
- 单核酸多态 (SNP) 可能会影响同时发展这两种疾病的风险.
研究的目的:
- 调查基因SNP与抑郁症和心血管疾病的并发症之间的关联.
- 系统地审查有关与抑郁症和心脏病相关的遗传变异的现有文献.
主要方法:
- 按照PRISMA-P指南进行系统审查.
- 包括病例控制和队列研究来评估基因SNP,抑郁症和心脏病.
- 使用纽卡斯尔-太华尺度 (NOS) 进行偏差风险评估.
- 使用五种模型 (等位基因,同卵性,共主导,主导,衰退) 分析遗传关联.
主要成果:
- 分析显示,5-HTTLPR基因多态和心血管疾病抑郁症 (CHD-D) 之间存在显著的关联,S等位基因是风险因素.
- BDNF基因 (rs6265) 多态性也与CHD-D有显著的关联,A等位基因被确定为危险因素.
- 在microRNA146a (rs2910164),ACE2 (rs2285666) 和SGK1 (rs1743963,rs1763509) 中的SNP被确定为CHD-D的风险因素.
- 欧洲人群与亚洲人群相比,与BDNF基因多态相关的CHD-D风险更高.
结论:
- 在5-HTTLPR,BDNF (rs6265),microRNA146a (rs2910164),ACE2 (rs2285666) 和SGK1 (rs1743963,rs1763509) 中的SNP与冠状动脉疾病中并发性抑郁症的出现有关.
- 未来的研究应该关注这些SNP对CHD-D的影响,特别是针对5-HTTLPR和BDNF基因.
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