玻璃化后冷保存持续时间对冷解芽细胞转移周期中单体出生体重的影响
Xue Wang1, Yaling Xiao1, Zhengyi Sun1
1Department of Gynecology Endocrine and Reproductive Center, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in endocrinology
|May 15, 2024
概括
长期冷保存为冷解的胚胎细胞转移 (FBT) 周期的胚胎细胞并没有显著影响单子出生体重. 然而,延长存储超过两年可能与低出生体重风险的潜在增加有关.
科学领域:
- 生殖医学和辅助生殖技术
- 新生儿结果和围产期健康状况
背景情况:
- 人类胚胎的冷保存,特别是胚胎囊,是辅助生殖的基石,可以保护生育能力并优化治疗周期.
- 长期冷保存囊的安全性及其对后续新生儿结果,特别是出生体重的影响需要持续调查.
研究的目的:
- 调查胚胎囊玻璃化后冷保存的持续时间与冷融化胚胎囊转移 (FBT) 周期中的单体出生体重之间的关联.
- 评估长期存储胚胎对辅助生殖结果的安全性.
主要方法:
- 追溯观察性研究包括1511名在2006年至2021年期间在FBT后分娩单子的患者.
- 根据冷保存的持续时间 (<3个月,3-6个月,6-12个月,12-24个月,>24个月) 将患者分为五组.
- 新生儿结局,包括出生体重,早产和低出生体重,通过多变量线性回归分析在不同组中进行了比较.
主要成果:
- 在五个冷保存持续时间组 (P > 0.05) 中,没有观察到平均出生体重的显著差异.
- 在所有组中,早产,低出生体重和妊娠年龄适当体重 (SGA/LGA) 的变化发生率都相似 (P > 0.05).
- 虽然经过对混因子进行调整后,注意到增加低出生体重风险与长期冷保存的趋势,但相关性在统计学上并不显著 (P > 0.05).
结论:
- 在FBT循环中,使用开放装置两年以上冷保存囊并没有显著影响单体出生体重.
- 临床医生应该保持警,因为潜在的,虽然不是统计学上显著的,低出生体重的风险增加,加长了冷保存的持续时间.
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