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总剂量,分剂量和呼吸运动管理影响上腺SBRT结果

Ory Haisraely¹, Ilana Weiss¹, Marcia Jaffe²

¹Sheba Medical Center, Radiation Oncology Unit, Israel.

Clinical and translational radiation oncology

|May 15, 2024

概括

对上腺转移的立体体辐射疗法 (SBRT) 是安全有效的. 较高剂量 (BED> 75 Gy),较高分量剂量 (> 8 Gy) 和运动管理可以改善局部控制,帮助治疗决策.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

立体性身体辐射疗法 (SBRT) 是一种被公认的对寡头转移性疾病的治疗方法.
对于长期局部控制上腺转移的最佳辐射剂量仍未确定.
上腺转移代表了放射治疗具有挑战性的位置,因为它靠近重要器官.

研究的目的:

评估SBRT对上腺转移的结果.
为了确定与上腺SBRT局部控制相关的因素.
评估SBRT在治疗上腺病变中的安全性和有效性.

主要方法:

在2015-2021年期间,对83名接受SBRT治疗上腺转移的患者进行了回顾性审查.
使用10的α/β比率计算生物有效剂量 (BED).
分析使用卡普兰-梅尔和考克斯回归来确定局部控制和生存的预测因素.

主要成果:

剂量> 75 Gy BED (HR=0.41,p=0.031),剂量> 8 Gy 每个分数 (HR=0.53,p=0.038),和运动管理 (喘息/CPAP) (HR=0.65,p=0.047) 与改善的局部控制显著相关.
在44%的患者中,非小细胞肺癌是首要诊断.
88%的病例在治疗期间使用呼吸控制技术.

结论:

单边上腺SBRT是安全的;双边治疗带有上腺功能衰竭的风险.
生物有效剂量> 75 Gy,运动管理 (喘息/CPAP) 和每小部分剂量> 8 Gy增强了局部控制.
开发了一种预测性名图,以协助对上腺SBRT的治疗计划.

关键词:

上腺上腺分数分数分数分数.当地控制局部控制运动管理运动管理在SBRT和SBRT之间.

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