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原蛋白通过增加DNA修复来防止缺血性中风

Niu Ping¹, Kuiyang Zuo², Jiahan Cai³

¹Department of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.

Frontiers in pharmacology

|May 15, 2024

概括

乙基 (APG) 通过减少氧化应激和DNA损伤,减少缺血性中风 (IS) 后的神经损伤. APG还增强了DNA修复机制,促进了IS的恢复.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

缺血性中风 (IS) 涉及显著的氧化应激和DNA损伤.
作为天然抗氧化剂的apigenin (APG) 在IS治疗中表现有前途,但其对DNA修复的影响尚不清楚.

研究的目的:

调查阿皮基因 (APG) 在缺血性中风 (IS) 后的DNA修复中的机制.

主要方法:

建立了一个永久的中脑动脉封闭 (pMCAO) 鼠标模型.
在中风前服用不同剂量的APG (30-120 mg/kg).
分析了脑损伤标志物,抗氧化剂状况和DNA修复蛋白,使用分子对接,MD模拟,免疫组织化学和西欧涂抹.

主要成果:

治疗APG可以减少心脏病发作量,大脑胀和神经缺陷.
APG抑制了PARP1/AIF通路,降低了帕尔塔纳托斯和亡.
APG增强了抗氧化能力和调节了DNA修复蛋白,促进了同源重组 (BRCA1,RAD51),同时减少了非同源末端连接 (KU70).

结论:

原蛋白 (APG) 通过减轻氧化应激和DNA损伤,在缺血性中风 (IS) 中提供神经保护.
APG积极改善DNA修复通路,有助于其在IS的治疗效果.

关键词:

它们的原生素是apigenin.同类的重组修复复合.缺血性中风中风不同类的终端链路维修帕塔纳托斯帕塔纳托斯帕塔纳托斯

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