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评估spns2-依赖的s1p传输作为潜在的治疗目标.

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  • 药理学 药理学是指药理学的学科.
  • 药物发现 药物发现 药物发现

    • 背景情况:

    • 氨酸1-酸盐 (S1P) 受体调节剂 (SRMs) 通过降低淋巴细胞S1P受体的调节来治疗自身免疫性疾病,但会引起像胸等副作用.
    • S1P 载体,如双胞胎同源2 (Spns2),为淋巴细胞受体提供S1P,表明其抑制是另一种治疗策略.
    • 缺少Spns2会导致淋巴细胞衰减和低淋巴S1P,这表明Spns2在免疫细胞定位中的作用.

    结论:

    • 通过STBs抑制S1P传输为免疫调节提供了潜在的治疗途径,与SRM相比,其安全性更好.
    • 通过STB最大的淋巴细胞减少小于SRM,可能是由于对T淋巴细胞亚群的差异性影响.
    • 淋巴体S1P度在STB治疗后保持不变,这表明对S1P传输抑制机制的理解不完全.