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Updated: Jun 26, 2025

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
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Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

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作为细胞内pH传感器的Gαi的分子和功能分析

Ajit Prakash1, Zijian Li1, Venkata R Chirasani1

  • 1Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Research square
|May 15, 2024
PubMed
概括

细胞内pH值的变化改变了Gαi蛋白的结构和稳定性,影响了G-蛋白结合受体 (GPCR) 信号传递. 这项研究揭示了Gαi中的pH感应网络,为涉及GPCR通路的疾病提供了新的治疗点.

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Simultaneous pH Measurement in Endocytic and Cytosolic Compartments in Living Cells using Confocal Microscopy09:46

Simultaneous pH Measurement in Endocytic and Cytosolic Compartments in Living Cells using Confocal Microscopy

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