通过具有广泛特异性的受体结合域单克隆抗体对SARS-CoV-2 JN.1和其他变体进行强有力的中和
bioRxiv : the preprint server for biology
|May 15, 2024
概括
一种新的人类单克隆抗体1301B7有效地中和了各种SARS-CoV-2变体,包括Omicron JN.1. 这种抗体显示出预防和治疗COVID-19感染的广泛潜力.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 结构生物学 结构生物学
背景情况:
- SARS-CoV-2 的演变需要新的预防和治疗策略.
- 目前的干预措施面临的挑战是由于病毒抗原的多样化,特别是在尖蛋白.
结论:
- hmAb 1301B7有效降低呼吸道中的病毒负担,并保护小鼠免受Omicron XBB1.5和JN.1挑战.
- 1301B7在预防和治疗临床SARS-CoV-2感染方面表现出广泛的潜力.
- 这些发现支持开发基于RBD的通用SARS-CoV-2疫苗和治疗方法.
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