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Updated: Jun 26, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
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弗洛蒂林-2抑制T细胞抗原敏感性和功能

Sookjin Moon, Fei Zhao, Mohammad N Uddin

    bioRxiv : the preprint server for biology
    |May 15, 2024
    PubMed
    概括

    移除支架蛋白Flotillin-2 (Flot2) 会增强T细胞对抗原刺激的敏感性. 这促进了T细胞信号传递和免疫反应,为治疗癌症等疾病提供了潜力.

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    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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    When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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