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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

709
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
709
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K

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H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment.

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CRAC channel activity pulsates during cytosolic Ca<sup>2+</sup> oscillations.

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Flotillin-2 dampens T cell antigen sensitivity and functionality.

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Plasma Membrane Ca<sup>2+</sup> ATPase Activity Enables Sustained Store-operated Ca<sup>2+</sup> Entry in the Absence of a Bulk Cytosolic Ca<sup>2+</sup> Rise.

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A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

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相关实验视频

Updated: Jun 26, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

1.9K

弗洛蒂林-2抑制T细胞抗原敏感性和功能.

Sookjin Moon, Fei Zhao, Mohammad N Uddin

    bioRxiv : the preprint server for biology
    |May 15, 2024
    PubMed
    概括
    此摘要是机器生成的。

    移除支架蛋白Flotillin-2 (Flot2) 会增强T细胞对抗原刺激的敏感性. 这促进了T细胞信号传递和免疫反应,为治疗癌症等疾病提供了潜力.

    科学领域:

    • 免疫学 免疫学 免疫学
    • 细胞生物学 细胞生物学
    • 分子生物学分子生物学

    更多相关视频

    Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes
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    Published on: July 15, 2011

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    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry
    08:35

    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry

    Published on: January 7, 2019

    11.5K

    相关实验视频

    Last Updated: Jun 26, 2025

    Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
    08:30

    Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

    Published on: May 10, 2022

    1.9K
    Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes
    09:45

    Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes

    Published on: July 15, 2011

    17.0K
    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry
    08:35

    Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry

    Published on: January 7, 2019

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    背景情况:

    • T细胞受体 (TCR) 参与对T细胞激活至关重要,但在血膜的精确调节机制尚未完全理解.
    • 了解TCR信号值是如何调节的,是开发有效免疫疗法的关键.

    结论:

    • 弗洛蒂林-2 (Flot2) 通过影响血膜TCR聚类,作为T细胞激活敏感性的负调节剂.
    • 调节Flot2水平可能是一种治疗策略,用于增强T细胞反应性,在癌症和慢性感染等疾病中.
    • 这些发现为T细胞激活的分子调节及其对免疫媒介疾病的影响提供了新的见解.