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Updated: May 21, 2026

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
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Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

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使用HiScanner高分辨率检测单个细胞中的副本数变化

Yifan Zhao, Lovelace J Luquette, Alexander D Veit

    bioRxiv : the preprint server for biology
    |May 15, 2024
    PubMed
    概括

    使用先进的计算方法,HiScanner可以准确地检测单个细胞中的副本编号变化 (CNA). 该工具揭示了详细的CNA模式和瘤进化,改进了单细胞全基因组测序分析.

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    相关概念视频

    Comparing Copy Number Variations and SNPs02:26

    Comparing Copy Number Variations and SNPs

    Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
    Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...