氧化压力是ME/CFS和长期COVID的共同特征
bioRxiv : the preprint server for biology
|May 15, 2024
概括
长期COVID和肌痛性脑膜炎/慢性疲劳综合征共享了涉及氧化应激和氧化还原途径异常的潜在分子机制. 甲胺显示出治疗ME/CFS的女性T细胞过度增殖的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 长期COVID (LC) 影响全球数百万人,呈现出类似于肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 的复杂多系统症状.
- 由于缺乏有效的治疗方法和LC和ME/CFS的诊断标记,因此需要对它们的分子基础进行研究.
- 迫切需要确定这些衰弱条件的分子基础.
研究的目的:
- 研究ME/CFS和LC患者外周血液淋巴细胞的生物能特性和分子机制.
- 确定ME/CFS和LC的潜在诊断标志物和治疗点.
- 探索疾病病理学的性别特异性差异.
主要方法:
- 采用了流细胞测量,散装RNA-seq,质谱和系统化学分析.
- 研究了来自健康对照组,ME/CFS和LC患者的外周血液淋巴细胞.
- 评估了还氧化途径,氧化应激标志物和T细胞增殖.
主要成果:
- 无论是ME/CFS还是LC患者都表现出高氧化应激,特别是在记忆淋巴细胞中.
- 观察到反应性氧物种 (ROS) 清除途径的异常,包括谷氨和超氧化物脱酶水平.
- 发现了明显的性别特异性趋势,女性的ROS和含量较高,男性的脂质氧化损伤较大.
结论:
- ME/CFS和LC是机理上相关的疾病,具有共同的分子病理学.
- 定量化血细胞测量可能有助于诊断ME/CFS和LC.
- 甲胺显示出作为治疗T细胞增殖的治疗剂的潜力,这种T细胞增殖在女性ME/CFS患者中被观察到.
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