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超越临床试验:免疫疗法对约旦NSCLC的真实影响
Taher Abu Hejleh1,2, Karim AlSawalha1, Sufian Abdel Hafiz1
1Department of Internal Medicine, Medical Oncology, King Hussein Cancer Center, Amman, Jordan.
Frontiers in oncology
|May 15, 2024
概括
在约旦,针对晚期非小细胞肺癌 (NSCLC) 的真实免疫治疗结果低于临床试验. 包括中东人口在内的进一步研究对于更好的肺癌治疗代表性至关重要.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 评价约旦高级非小细胞肺癌 (NSCLC) 的真实世界免疫治疗结果.
- 在2017年至2022年期间,在侯赛因国王癌症中心 (KHCC) 评估治疗有效性.
研究的目的:
- 确定在晚期NSCLC患者中免疫治疗的实际有效性.
- 在一线免疫疗法接受者中确定总生存 (OS) 的预测因素.
主要方法:
- 对244名接受免疫治疗的晚期NSCLC患者的回顾性分析.
- 估计无进展生存 (PFS) 和OS,特别是对于ECOG性能状态 (ECOG PS) 0-1的患者.
- 考克斯回归分析用于确定一线免疫治疗中的OS预测因子.
主要成果:
- 160名患者接受了第一线免疫疗法 (1L IO),67人接受了第二线免疫疗法 (2L),17人接受了第三线免疫疗法或更高的免疫疗法.
- 1L IO的PFS和OS中位数分别为7个月和11.8个月.
- 与ECOG PS 0-1 (p=0.005) 相比,ECOG PS 2是更糟糕的OS的显著预测因素.
结论:
- 在约旦,晚期NSCLC的真实免疫疗法结果低于临床试验的预期.
- 对于将中东患者纳入肺癌临床试验的必要性至关重要,以更好地代表民族.
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