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Updated: Jun 19, 2026

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
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Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

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简单的光标记方法可以检测细胞内分布和表达水平的视网膜X受体

Yukina Tanaka1, Michiko Fujihara1, Yuta Takamura1

  • 1Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.

ACS medicinal chemistry letters
|May 15, 2024
PubMed
概括

研究人员开发了一种新的光探针,可视化细胞内的视网膜X受体 (RXR). 这种方法可以追踪RXR表达和核转位,有助于理解核受体动力学.

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...