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新生儿肠道微生物群和益生菌干预的起源:一个随机对照试验

Zhe Li¹, Yiwen Zhang¹, Xiaozhi Tan¹

¹Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Frontiers in nutrition

|May 15, 2024

概括

孕产妇的肠道微生物群显著影响新生儿的肠道微生物群,胎盘会影响美. 怀孕期间的益生菌干预改变了一些母亲和婴儿肠道细菌的组成.

科学领域:

微生物学微生物学
孕产妇和胎儿的健康状况
胃肠病学胃肠病学

背景情况:

早期的肠道微生物群对婴儿健康至关重要.
了解新生儿肠道微生物群的起源对于开发有针对性的干预措施至关重要.
母亲因素,包括饮食和微生物暴露,显著塑造婴儿微生物组.

研究的目的:

为了调查新生儿肠道微生物群在生命的第14天的起源.
评估孕期第三季度益生菌干预对孕妇和新生儿肠道微生物群的影响.
确定母体微生物群 (肠道,阴道,胎盘) 对新生儿肠道微生物群组成的影响.

主要方法:

用V4区域的16SrRNA扩增序列测序来分析微生物组成.
在社区分析中使用非度量多维缩放 (NMDS).
使用SourceTracker追踪新生儿肠道微生物群的起源.

主要成果:

新生儿肠道微生物群的组成与不同时间点的母体微生物群相关.
胎盘显示出对美微生物群的显著影响.
产后的第3天和第14天,母亲的肠道微生物群对新生儿的肠道微生物群产生了更大的影响.
益生菌干预并没有显著改变母体或新生儿样本中关键细菌 (Bifidobacterium,Lactobacillus,Streptococcus) 的丰富性,但诱导了其他细菌种群的变化.

结论:

母亲肠道微生物群是新生儿肠道微生物殖民的主要决定因素.
样本采集和输送方式的时间影响了观察到的微生物起源.
虽然特定的益生菌菌株并没有显著改变主导细菌群体,但更广泛的微生物群体中的微妙转变需要进一步调查.

关键词:

我们的肠道微生物群.新生儿肠道微生物群胎盘中的微生物群.益生菌是一种益生菌.阴道的微生物群.

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