按出生大小的生长模式,在头3年内,早产儿出生于24-29个妊娠周
Tanis R Fenton1, Lauren Samycia2, Seham Elmrayed1,3
1Community Health Sciences, O'Brien Institute of Public Health, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Paediatric and perinatal epidemiology
|May 15, 2024
概括
大多数早产婴儿在怀孕30周之前出生,在3岁时追上生长图.经过年龄校正. 过早生长的婴儿的早期增长迟缓,其预测以后的认知成绩的能力有限.
科学领域:
- 新生儿科学 新生儿科学
- 儿科生长与发展 儿科生长与发展
- 围产儿医学 围产儿医学
背景情况:
- 过早出生的婴儿在出院后经常表现出不良生长,引发人们对衰老,体重不足和未来心脏代谢风险的担忧.
- 在极度和非常早产的婴儿中,长期生长轨迹及其预测因素需要进行彻底的调查.
研究的目的:
- 分析极度和非常早产婴儿的长度生长模式,直至3岁的年龄校正 (CA).
- 根据妊娠年龄 (小,适当,大) 根据出生体重对生长进行分类.
- 评估早期生长迟是否预测3岁CA时的认知结果.
主要方法:
- 预M成长队列研究跟踪了出院后的生长 (头部,长度,体重,体重对长度) 与世卫组织标准相比,用于怀孕30周以下和1500克以下的婴儿.
- 婴儿得到了多学科的支持;那些患有重大新生儿疾病的人被排除在外.
- 增长迟缓 (<-2 z-scores) 被分析为其对认知得分的预测能力.
主要成果:
- 虽然一些婴儿在妊娠36周时表现出人体测量值低于-2z-score,但大多数婴儿在3年CA时有所改善,很少有人 (<6%) 保持在-2z-score以下.
- 对于妊娠年龄 (SGA) 出生的婴儿在3岁CA时与适合妊娠年龄 (AGA) 婴儿相比,身高显著更短,体重更低.
- 增长不稳定表明在3年CA (AUROC 0.42) 预测认知得分的能力有限.
结论:
- 没有重大新生儿疾病的早产婴儿 (<30周妊娠期) 最初可能在生长图表上很低,但通常在3岁时达到追赶增长.
- 对于妊娠年龄的出生体重影响长期生长,SGA婴儿表现出持续的缺陷.
- 早期生长不稳定不是这个人群认知发育的可靠预测指标.
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