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相关概念视频

Sample Size Calculation01:19

Sample Size Calculation

3.3K
Knowledge of the sample size is the first requirement to conduct random sampling or an experiment. The sample size is the total number of units, observations, or groups (in some cases) used to get the data to estimate a population parameter. As the name suggests, the sample size is that of the sample drawn from the population and differs from the population size.
The sample size for the given experiment or sampling effort is fundamental to any study design. Sample size decides the number of...
3.3K
Testing a Claim about Standard Deviation01:19

Testing a Claim about Standard Deviation

2.4K
A complete procedure to test a claim about population standard deviation or population variance is explained here.
The hypothesis testing for the claim of population standard deviation (or variance) requires the data and samples to be random and unbiased. The population distribution also must be normal. There is no specific requirement on the sample size as the estimation is based on the chi-square distribution.
As a first step, the hypothesis (null and alternative) concerning the claim about...
2.4K
Testing a Claim about Population Proportion01:24

Testing a Claim about Population Proportion

3.3K
A complete procedure for testing a claim about a population proportion is provided here.
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
3.3K
Testing a Claim about Mean: Unknown Population SD01:21

Testing a Claim about Mean: Unknown Population SD

3.4K
A complete procedure of testing a hypothesis about a population mean when the population standard deviation is unknown is explained here.
Estimating a population mean requires the samples to be approximately normally distributed. The data should be collected from the randomly selected samples having no sampling bias. There is no specific requirement for sample size. But if the sample size is less than 30, and we don't know the population standard deviation, a different approach is used;...
3.4K
Wald-Wolfowitz Runs Test II01:17

Wald-Wolfowitz Runs Test II

227
The Wald-Wolfowitz runs test, commonly referred to as the runs test, is a nonparametric test used to assess the randomness of ordered data. The test evaluates the number of runs, which are consecutive sequences of similar elements within the data. If the number of runs is significantly higher or lower than expected, the data is considered non-random, indicating a detectable pattern or structure.
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and...
227
Sign Test for Matched Pairs01:17

Sign Test for Matched Pairs

129
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
129

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相关实验视频

Updated: Jun 26, 2025

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
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Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

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样本大小计算用于比较两个选试验,当黄金标准随机缺失时.

Yougui Wu1

  • 1Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, Florida, USA.

Statistics in medicine
|May 15, 2024
PubMed
概括

本研究引入了更简单的样本大小公式来比较诊断测试准确性,解决对设计中的验证偏差. 新的方法更容易使用,并产生与复杂的现有方法相似的结果.

科学领域:

  • 生物统计学 生物统计学
  • 医学诊断 医学诊断 医学诊断
  • 临床试验 临床试验

背景情况:

  • 比较诊断测试准确度至关重要,特别是在验证偏差的情况下.
  • 对于配对设计的现有样本大小公式是复杂的,并且很难实现.
  • 在评估诊断测试性能的研究中,配对设计是常见的.

研究的目的:

  • 提出简化和直观的样本大小公式来比较两个灵敏度或特异性.
  • 为配对设计提供现有复杂公式的实用替代方案,以提供具有验证偏差的复杂公式.
  • 在样本大小计算中比较不同统计测试的效率.

主要方法:

  • 为两个沃尔德试验和一个加权麦克纳马斯试验开发替代样本大小公式.
  • 拟议公式与现有的复杂方法进行比较.
  • 分析不同测试中的样本大小要求,考虑不一致和一致的对.

主要成果:

  • 拟议的样本大小公式比现有的样本大小公式更简单,更直观.
  • 所有三个考虑的测试 (两个沃尔德,一个加权的麦克纳马斯) 都导致类似的样本大小.
  • 只有使用不一致对的权重麦克纳马尔测试,显示了与使用一致和不一致对的沃尔德测试相比较的样本大小需求.
关键词:
这是McNemar的测试.沃尔德的测试是对沃尔德的测试.样本大小计算 样本大小计算验证偏差是因为存在验证偏差.权重的麦克纳马尔的测试.

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结论:

  • 简化样本大小计算现在可用于配对的诊断准确性研究,具有验证偏差.
  • 选择的测试 (瓦尔德与加权的麦克纳马斯) 并不会显著影响样本大小要求.
  • 这些发现有助于在诊断测试评估中更容易获得和更有效的研究设计.