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Updated: Jun 26, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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AlphaFind:在AlphaFold DB中发现整个蛋白质组的结构相似性

David Procházka1, Terézia Slanináková1,2, Jaroslav Olha1,2

  • 1Faculty of Informatics, Masaryk University, Botanická 68A, Brno 60200, Czech Republic.

Nucleic acids research
|May 15, 2024
PubMed
概括

AlphaFind是一个新的网络工具,用于从AlphaFold DB中快速检索蛋白质结构. 它使用机器学习根据3D特征识别相似的蛋白质结构,帮助研究人员进行结构分析.

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Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Globular and Fibrous Proteins

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
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Protein Folding

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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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