老年患者鼻内维生素B12:对两个剂量方案进行随机对照的比较
Monique P H Tillemans1,2,3, Thijs J Giezen1,2,4, Toine C G Egberts3,4
1Pharmacy Foundation of Haarlem Hospitals, Haarlem, The Netherlands.
British journal of clinical pharmacology
|May 15, 2024
概括
鼻内维生素B12有效地补充了缺乏的老年患者的维生素B12水平. 加重剂量方案显示出更快的初始增加,而无负载剂量方案在90天内提供了持续水平.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 维生素B12缺乏症在老年人中很普遍.
- 肌肉内注射,标准治疗,存在缺点.
- 鼻内维生素B12提供了一个潜在的更安全,更方便的替代品.
研究的目的:
- 为了比较两种内维生素B12剂量方案,在老年患者中使用维生素B12缺乏.
- 评估内维生素B12在恢复和维持维生素B12水平方面的疗效.
主要方法:
- 参与了60名65岁及以上的维生素B12缺乏症患者.
- 参与者被随机分为两组:充满剂量疗法 (每天14天,然后每周一次) 或无负载剂量疗法 (每3天一次).
- 血清维生素B12,全转糖胺 (holoTC),甲基马龙酸 (MMA) 和总同型半氨酸 (tHcy) 在90天内被测量.
主要成果:
- 这两种疗法都迅速增加了维生素B12和HoloTC水平,使MMA和THcy正常化.
- 加重剂量方案实现了最快和最高的维生素B12增加 (14天的中位数为1090 pmol/L).
- 无负载剂量方案导致维生素B12水平持续 (90天的中位数为717 pmol/L).
结论:
- 鼻腔内注射维生素B12是老年患者的有效方法.
- 这一途径成功地补充并维持维生素B12水平.
- 鼻内注射维生素B12是传统肌内注射的合适替代品.
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