控制产前甲状腺查研究III:孕期甲状腺状况对青少年大脑形态的影响
Anna Scholz1, Carolyn B McNabb2, Laura Bloomfield2
1Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
The Journal of clinical endocrinology and metabolism
|May 15, 2024
概括
怀孕期间母亲的甲状腺功能没有影响青少年的大脑发育. 妊娠时甲状腺功能低于最佳 (SGTF) 和甲氧治疗与儿童的大脑形态没有关联.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
背景情况:
- 怀孕期间母亲的甲状腺功能障碍可能会影响胎儿的神经发育.
- 孕期甲状腺功能 (SGTF) 对后代大脑发育的确切影响尚不清楚.
研究的目的:
- 调查SGTF与青少年大脑形态学的关联.
- 为了评估为SGTF补充levothyroxine对大脑发育的影响.
主要方法:
- 控制产前甲状腺查 (CATS) III研究在85名青少年 (年龄11-16岁) 中使用了T1加权的结构性MRI.
- 参与者根据母亲的妊娠甲状腺状况进行分类:未经治疗的SGTF,正常的妊娠甲状腺功能 (GTF) 和治疗的SGTF (最佳或过度治疗).
- 分析检查了全球和次区域的大脑体积,将它们与母亲的甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4) 水平相关联.
主要成果:
- 两组之间没有观察到包括灰质在内的全球大脑体积的显著差异.
- 孕产妇的TSH水平和一些大脑体积之间的微弱正相关性在多次比较中无法经受校正.
- 母亲的自由甲状腺素 (FT4) 水平与大脑体积没有显著的关联.
结论:
- SGTF与青少年大脑形态的改变无关.
- 对SGTF的Levothyroxine补充剂在这个队列中没有对大脑发育产生明显的影响.
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