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Updated: Jun 26, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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为了不对称合成德克斯特罗梅索芬关键中间体的工程化伊米因降解酶

Xiaofeng Lin1,2, Yixuan Li2,3, Zefei Xu2

  • 1School of Biotechnology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.

Organic letters
|May 15, 2024
PubMed
概括

(S) - 1 - 4 - - 甲基) - - 八化素 ((S) - 1 - 4 - - 甲基) - - OHIQ) 是德克斯特罗梅多芬的关键中间体. 酶工程创造了一种变体 (M4),效率高766倍,使得有效的工业合成成为可能.

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