在移植患者中优化SARS-CoV-2疫苗反应:迫切需要
Yi-Ling Cheng1, Shen-Shin Chang2, Chiao-Hsuan Chao3
1Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Microbiology spectrum
|May 15, 2024
概括
移植接受者 (KTRs) 对SARS-CoV-2疫苗的免疫反应较弱,抗体和T细胞活性较低. 这凸显了在韩国地区加强疫苗接种战略的必要性,以提高对COVID-19的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
- 病毒学 病毒学
背景情况:
- 移植接受者 (KTRs) 患有严重的SARS-CoV-2结局的风险更高.
- 以前的研究表明,KTRs可能会降低对SARS-CoV-2疫苗的血清反应.
- 有限的数据存在于KTRs疫苗接种后的细胞免疫反应.
研究的目的:
- 研究和比较KTRs与健康捐赠者的SARS-CoV-2疫苗的血清和细胞免疫反应.
- 评估疫苗接种后的KTR抗体水平和T细胞功能,包括细胞因子分泌.
主要方法:
- 在7名KTR和6名健康捐赠者中评估了抗体水平 (抗RBD,中和抗体) 和T细胞反应 (CD8T细胞细胞毒性,Th1细胞因子分泌) 疫苗接种后.
- 刺激的外周血液单核细胞 (PBMCs) 来自与 SARS-CoV-2 尖峰池的参与者.
主要成果:
- KTRs表现出明显较低的抗体反应,包括减少对武汉,三角洲和Omicron BA.2菌株的中和抗体.
- 刺激后,KTRs显示CD8 T细胞细胞毒性反应较弱,Th1细胞因子分泌减少,特别是干扰因子- (IFN-γ).
- 与健康个体相比,KTRs观察到IFN-γ分泌量的显著减少.
结论:
- 在SARS-CoV-2疫苗接种后,KTRs表现出受损的血清和细胞免疫力.
- 这些发现强调了需要专门的策略来增强KTRs的疫苗诱导免疫反应.
- 需要进一步的研究,以了解在KTR中疫苗有效性降低的机制,并探索治疗干预措施.
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