乳球球菌克雷莫里斯D2022缓解高尿血并通过潜在的肠轴抑制炎
Zhihuan Wang1, Yuanming Huang1, Tao Yang1
1National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center of Disease Control and Prevention, Beijing, China. renzhihong@icdc.cn.
Food & function
|May 15, 2024
概括
一种新型益生菌Lactococcus cremoris D2022有效降低高尿酸水平,并减少脏炎症. 这种菌株增强了肠道健康和全身新陈代谢,为高尿血症提供了有前途的新疗法.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 免疫学 免疫学 免疫学
背景情况:
- 超尿血症 (HUA) 是一种普遍的代谢障碍,益生菌治疗的有效性有限.
- 益生菌的血清尿酸 (SUA) 降低效应背后的机制需要进一步阐明.
- 对于HUA管理,需要新型益生菌菌株,其有效性已被证明.
研究的目的:
- 为了识别和表征一种新的益生菌菌株,以其缓解高尿血症的能力.
- 研究益生菌菌株降低SUA水平和脏炎症的机制.
- 评估益生菌对肠道健康,新陈代谢和肠道屏障功能的影响.
主要方法:
- 在使用氧酸盐和腺因的小鼠模型中诱导高尿血.
- 使用一种新型乳球球菌菌D2022菌株.
- 对血清尿酸水平,尿酸合成和输送途径的分析.
- 评估脏炎症标志物,NLRP3炎症酶通路和自由脂肪酸受体 (FFARs).
- 测量短链脂肪酸 (SCFA) 在样和血清非向代谢学.
- 评估肠道屏障功能的评估.
主要成果:
- 乳球球菌克雷莫里斯D2022通过抑制合成和调节运输,显著降低了血清尿酸水平.
- 益生菌减轻了HUA诱导的炎,涉及NLRP3相关途径和FFARs.
- 口服D2022增加了内SCFA,这表明减少炎的机制.
- 代谢分析显示了与纯素代谢和炎症相关的系统生物活性.
- 乳球球菌 D2022 改善了肠道屏障的功能.
结论:
- 乳球球菌克雷莫里斯D2022在治疗高尿血和相关病方面具有显著的潜力.
- 益生菌通过调节尿酸代谢,通过SCFA减少炎症,改善肠道屏障功能来发挥其作用.
- 这项研究强调了乳球球菌cremoris D2022作为一个有前途的补充治疗超尿血.
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