在小鼠中,位于腹部淋巴结和子宫/前列腺之间的一种新型脂肪组织的表征
Lihao Hu1,2,3, Gaochen Zhang1,2,3, Xiaoyu Tong4
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, People's Republic of China.
概括
研究人员在雌性小鼠中发现了一种新的棕色的脂肪组织 (AT),称为淋巴结-宫AT (LNCAT). 这种组织组织.
科学领域:
- 脂肪组织生物学 脂肪组织生物学
- 比较生理学比较生理学
- 内分泌学 在内分泌学.
背景情况:
- 周围脂肪组织 (AT) 通常是雄性小鼠的白色脂肪组织 (WAT).
- 男性和女性生殖腺之间存在先天性差异.
- 雌性围腺AT的异质性仍然未被探索.
研究的目的:
- 在雌性小鼠中识别和描述新的脂肪组织储存.
- 为了研究雌性小鼠中围性AT的表型特征.
- 探索这个新的AT仓库的功能调节.
主要方法:
- 脂肪组织储存的组织学分析.
- 对解蛋白1 (UCP1) 表达的评估.
- 研究冷气诱导的热生成.
- 激素操纵 (雄激素,雌激素,孕激素) 和割模型.
主要成果:
- 在雌性小鼠中发现了一种新的棕色类型的AT,淋巴结-宫AT (LNCAT).
- LNCAT及其男性对应物 (LNPAT) 呈现出涉及腹部淋巴结的冷诱导性UCP1表达.
- 在LNCAT/LNPAT中的UCP1表达是由生殖阶段,性别和交配行为调节的.
- 雄激素抑制了UCP1的表达,逆转了割引起的色.
结论:
- 在雌性小鼠中发现了一种新型的围膜棕色类AT (LNCAT).
- 腹部淋巴结在冷引起的LNCAT棕色化中起作用.
- 雄激素作为LNCAT/LNPAT中的UCP1表达的抑制剂,在不同的生理状态中影响其热生成能力.
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