通过减少α-Fetoprotein,SARS-CoV-2感染增加了唐氏综合征查测试的高风险率
Clinical laboratory
|May 15, 2024
概括
怀孕早期的COVID-19感染可能会增加唐氏综合征查测试的阳性,因为改变了AFP和β-hCG水平. 然而,SARS-CoV-2感染似乎没有增加胎儿唐氏综合征的实际发病率.
科学领域:
- 孕产妇和胎儿的医学
- 传染病流行病学 传染病流行病学
- 产前诊断 在产前诊断
背景情况:
- COVID-19 流行病对孕妇和胎儿构成风险.
- 怀孕增加了对严重SARS-CoV-2感染的易感性.
- 以前的研究表明,COVID-19可能会使怀孕复杂化.
研究的目的:
- 研究SARS-CoV-2感染对唐氏综合征查标志物的影响.
- 评估COVID-19是否会影响阳性唐氏综合征查测试的可能性.
- 确定SARS-CoV-2感染与胎儿唐氏综合征发生之间的关联.
主要方法:
- 使用粒子化学发光试验进行血清学测试.
- 将孕妇分为未感染者,早期妊娠期 (≤6周) 感染SARS-CoV-2,以及晚期妊娠期 (>6周) 感染SARS-CoV-2的组.
- 分析α-fetoprotein (AFP) 和自由β人类胆激素 (β-hCG) 水平以及唐氏综合征查测试阳性率.
主要成果:
- 妊娠早期的SARS-CoV-2感染与AFP降低和较高的唐氏综合征查测试阳性度相关 (p<0.05).
- 妊娠后期的SARS-CoV-2感染显示,阳性查率的非显著增加 (6.2%与5.7%,p>0.05).
- 与对照组相比,晚期妊娠期感染与β-hCG水平降低有关 (p<0.05),但没有观察到唐氏综合征发病率增加.
结论:
- 怀孕期间的SARS-CoV-2感染可能导致母亲血清标志物水平 (AFP,β-hCG) 发生变化.
- 感染SARS-CoV-2的孕妇可能有更高的可能性呈阳性唐氏综合征查结果.
- 这项研究没有发现证据表明SARS-CoV-2感染会增加胎儿唐氏综合征的实际发病率,因此需要进一步调查.
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