在2型糖尿病中,血清神经调节素-1和动脉动脉生成指数之间的联系
Wafaa Sh Al-Zuhairi1, Leila Sadeghi2,3, Ekhlas Abdallah Hassan4
1Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Irish journal of medical science
|May 15, 2024
概括
在2型糖尿病 (T2DM) 患者中发现较低的神经调节素-1 (NRG-1) 水平,与较高的动脉动脉指数 (AIP) 和心血管疾病 (CVD) 风险增加相关.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 神经调节素-1 (NRG-1),一种表皮生长因子,在心肌中表现出抗纤维的作用.
- 这项研究研究了NRG-1在2型糖尿病 (T2DM) 中的作用及其与心血管疾病 (CVD) 风险因素的动脉动脉指数 (AIP) 的关联.
研究的目的:
- 在T2DM患者中评估血清NRG-1水平.
- 确定NRG-1水平,AIP和T2DM中心血管疾病风险之间的关系.
主要方法:
- 79名T2DM患者 (53名女性,26名男性,年龄在40-67岁) 根据AIP分为两组:高心血管疾病风险 (I组,n=48) 和没有心血管疾病风险 (II组,n=31).
- 40名健康人群作为对照组.
主要成果:
- 与对照组相比,T2DM患者的血清NRG-1水平明显较低 (p=0.01).
- 第一组 (高心血管疾病风险) 的NRG-1水平低于第二组.
- 血无气指数 (AIP) 是NRG-1水平的唯一独立预测指标 (β=-0.600,P=0.040).
- 在糖尿病患者中诊断高心血管疾病风险的曲线下的面积 (AUC) 为0.889 (P=0.001).
结论:
- 糖尿病患者显示NRG-1水平降低.
- 更高的NRG-1水平与更有利的AIP有关.
- NRG-1测量可以作为监测T2DM中心血管疾病风险的宝贵生物标志物.
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