一个电压辅助的16通道电化学生物传感器,具有线性补偿
IEEE transactions on biomedical circuits and systems
|May 15, 2024
概括
本研究引入了一种双模式采集技术,以减少电极电容负载引起的电化学测量误差. 该方法提高了检测准确度,并降低了像Interleukin-6这样的测试的检测极限.
科学领域:
- 电化学传感器技术电化学传感器技术
- 生物医学信号处理
- 低功率的集成电路设计设计.
背景情况:
- 电极电容负载会导致显著的误差电流和电化学信号采集中的解决问题.
- 现有的方法很难准确地捕捉和补偿这些非线性,从而影响整体测量可靠性.
研究的目的:
- 开发一种高效的电流和电压双模式采集技术,以减轻电极电容负载引起的不准确性.
- 为了减少电化学信号采集系统的复杂性和功耗.
主要方法:
- 使用电压前端 (VFE) 来获取和补偿电极电压错误和非线性.
- 一个基于逆变器的电容式传 impedance 放大器 (IB-CTIA) 被用于增强输入传导率以实现低噪声性能.
- 该技术通过在180纳米CMOS工艺制造的原型芯片上使用Interleukin-6 (IL-6) 免疫测试来验证.
主要成果:
- IB-CTIA实现了低输入参考电流噪声 (3.9 pArms) 和高动态范围 (126 dB) 与低静态功耗 (18 μW).
- 非线性错误补偿使IL-6检测结果的相关系数从0.951提高到0.980.
- 对IL-6的检测极限 (LoD) 从8.31 pg/mL降至6.90 pg/mL.
结论:
- 拟议的电流和电压双模式采集技术有效地弥补了电极电容负载在电化学测量中的错误.
- 这种方法提高了检测精度和灵敏度,使其适合低功耗,高性能生物传感应用.
- 当前前端的宽松增益和带宽要求简化了电路设计并降低了功耗.
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