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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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博尔特佐米布抑制了20S蛋白质组的开放配置

Lucas W Henderson1, Amit K S Gautam2, Edie M Sharon1

  • 1Department of Chemistry, Indiana University, Bloomington, Indiana 47401, United States.

Journal of the American Society for Mass Spectrometry
|May 15, 2024
PubMed
概括

博尔特佐米布是一种蛋白质酶体抑制剂,将20S蛋白质酶体锁定到紧状态,抑制门的打开. 这种结构变化可能会阻止基质进入,影响蛋白质降解途径.

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