关于印度健康儿童和青少年胰岛素样生长因子1的规范性数据
Kasagani Venkata Ravi Teja1,2, Bhanu Malhotra1, Mandy Vogel3
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
The Journal of clinical endocrinology and metabolism
|May 15, 2024
概括
这项研究确定了印度儿童血清胰岛素样生长因子1 (IGF-1) 的关键,种族特异性参考数据. 这些新的IGF-1规范将加强该人口中生长激素障碍的诊断和管理.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生物化学 生物化学
- 生长激素研究 研究生生长激素研究
背景情况:
- 血清胰岛素样生长因子1 (IGF-1) 对于诊断生长激素 (GH) 相关疾病至关重要.
- 现有的IGF-1规范数据缺乏特定种族的印度数据,这阻碍了准确的临床应用.
- 需要基于共识标准的可靠,印度特有的IGF-1参考范围.
研究的目的:
- 为了生成血清IGF-1的年代年龄 (CA),骨年龄 (BA) 和坦纳阶段特定的规范性数据.
- 为健康的印度儿童和青少年建立特定于种族的IGF-1参考范围.
- 提高IGF-1的诊断实用性,以评估印度儿科生长障碍.
主要方法:
- 一项横截面的流行病学研究招募了1948名健康的印度儿童和青少年.
- 使用电化学发光免疫测试 (ECLIA) 来测量血清IGF-1水平.
- 一般化添加剂模型根据CA,BA和Tanner阶段估计了IGF-1的2.5至97.5个百分点.
主要成果:
- 与男孩相比,女孩在较年轻的CA和Tanner阶段表现出更早的IGF-1峰值.
- 平均IGF-1峰值在性别之间存在差异,女孩的水平更高.
- 在近青春期期间观察到IGF-1的更广泛的参考间隔,这表明生理变异性增加.
结论:
- 这项研究提供了印度儿童和青少年血清IGF-1的第一个种族特异性规范数据.
- 这些已确定的参考范围将大大提高IGF-1测定的诊断准确性.
- 提高IGF-1的诊断效用将有助于有效管理印度儿科人口中生长障碍.
关键词:
骨Xpert 专家 骨Xpert 专家在欧洲,ECLIALIA.在IGF-1的基础上,IGF-1丹尼尔阶段的阶段骨年龄 骨年龄 骨年龄年代年代年代年代年代年代年代年代年代年代规范性数据是指规范性数据.更多相关视频
相关概念视频
Insulin: Dosing Regimen and Adverse Effects
167
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
167
Hypoglycemia and Glucagon
257
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
257
Nature and Nurture
20.5K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K


