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Updated: Jun 26, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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从4-基甲化物中合成2-烯亚林的化学酶合成,使用香醇氧化酶

Haowen Zhang1, Shuhan Xie2, Jun Yang1,3

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China.

Angewandte Chemie (International ed. in English)
|May 15, 2024
PubMed
概括

乙醇氧化酶 (VAO) 从易于获得的前体中有效合成2 - 烯 thiazolines. 蛋白质工程扩大了基质范围,使药物发现的新生物活性化合物合成成为可能.

关键词:
化学酶合成的化学酶合成绿色化学是一种绿色化学.蛋白质工程工程 蛋白质工程thiazolines 是一种类固醇.瓦尼基醇氧化酶是一种基醇氧化酶.

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