血液和在血友病B资源的使用:回顾性观察性研究
Lisa Young, Lu Ban, Yong Chen1
1Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426.
The American journal of managed care
|May 15, 2024
概括
患有乙型血友病 (PWHB) 的人,尽管接受治疗,但仍会出现出血,这会导致大量的医疗费用. 这些患者的住院率和急诊率较高,突出显示了大量的临床和经济负担.
科学领域:
- 血液学 血液学 血液学
- 药物经济学 药物经济学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 血友B是一种罕见的出血障碍,需要因子替代疗法.
- 一些患有乙型血友病 (PWHB) 的个人即使在治疗因子IX时也会出现出血.
- 了解这些突破性出血的负担对于医疗保健管理至关重要.
研究的目的:
- 描述美国PWHB的特征,尽管发生因子替代疗法,但仍有出血.
- 从第三方付款人的角度来量化医疗保健资源利用率和相关成本.
主要方法:
- 一项使用美国索赔数据 (PharMetrics Plus,2010-2019) 的观察性研究,研究了因子IX治疗中患有血友病B的成年男性.
- 患者根据医疗记录的出血 (MRB) 使用诊断代码对患者进行分类.
- 医疗保健资源的利用 (住院治疗,急救诊所,门诊) 和并发症被分析并按年龄分层.
主要成果:
- 与没有MRB的PWHB (n=345) 相比,没有MRB的PWHB (n=345) 有较高的全因住院率 (14.8/100人/年) 和ED访问率 (67.6/100人/年) 与没有MRB的PWHB (n=252) 相比.
- 住院患者和急救诊所的入院率分别是PWHB与MRB的2.5倍和2.7倍,在PWHB中,MRB的入院率分别是2.5倍和2.7倍.
- 伴随性疾病,特别是焦虑和抑郁,在PWHB中很普遍,在所有年龄组中,精神疾病总是很高.
结论:
- 经历突破性出血的PWHB需要大量的医疗保健资源利用.
- 与PWHB中医疗记录出血相关的临床和经济负担是相当大的.
- 心理健康状况的高患病率在管理PWHB时需要注意.
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