在乌干达实施多卢特格拉维尔的人口有效性:一个前性观察队列研究 (DISCO),48周的结果
Suzanne M McCluskey1,2,3, Winnie R Muyindike4, Victoria Nanfuka4
1Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
The Journal of infectious diseases
|May 15, 2024
概括
诺福维尔/拉米武丁/多卢特格拉维尔 (TLD) 疗法在艾滋病毒感染者从旧疗法过渡时显示出高的现实有效性. 这项研究证实了TLD.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 提诺福维尔/拉米武丁/多卢特格拉维尔 (TLD) 推作为艾滋病毒感染者 (PWH) 首选的第一线抗逆转录病毒疗法 (ART).
- 从非核酸逆转录酶抑制剂 (NNRTIs) 过渡到TLD是PWH的一个常见策略.
- 在各种环境中,TLD的现实有效性数据对于优化艾滋病毒治疗至关重要.
研究的目的:
- 估计乌干达公共部门诊所过渡到TLD的实际有效性.
- 评估PWH队列中TLD的病毒抑制率和耐受性.
- 为了识别与TLD使用相关的任何新出现的耐药性.
主要方法:
- 一项前性队列研究,涉及500名年龄≥18岁的PWH从基于NRTI的ART过渡到TLD.
- 转变后24周和48周进行后续访问,以评估病毒载量 (VL) 和不良事件.
- 对具有VL>500副本/毫升的参与者进行回顾性VL评估和基因型耐药性测试.
主要成果:
- 94%的参与者在TLD过渡后48周实现了病毒抑制 (<200副本/毫升).
- 只有2%的病毒载量>500拷贝/毫升,2%的患者因不良事件而停止了TLD治疗.
- 没有发现对多卢特格拉维尔 (DTG) 的抗药性事件.
结论:
- 病毒抑制的高率和良好的耐受性支持TLD作为首选的第一线ART疗法.
- 在乌干达的现实环境中,TLD制度证明了其有效性和安全性.
- 顶级域名是PWH的可行和有效的选择,包括以前在NNRTIs上的那些.
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