可降解的立体微粒的微流体组合
Gianna G Tutoni1, Samantha M McDonald1, Ruoyu Zhong2
1Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Journal of the American Chemical Society
|May 15, 2024
概括
这项研究引入了一种创新的方法,即使用立体复合,一种物理交叉连接技术来创建可调节的水凝微粒 (HMP). 这种方法避免了共价方法,为组织工程和药物输送提供了更多的转化相关的HMP.
科学领域:
- 生物材料科学
- 聚合物化学
- 组织工程
- 提供药物
背景情况:
- 在组织工程和药物输送方面,水凝微粒 (HMP) 是有前途的.
- 共价交联方法限制了HMP的转化潜力.
- 立体复合为HMP制造提供了一个强大的,可降解的替代方案.
研究的目的:
- 通过立体复杂化开发具有翻译意义的水凝微粒 (HMP).
- 为了证明可调整尺寸的明确HMP的制造.
- 确认立体复杂化并实现HMP的功能化.
主要方法:
- 聚合四臂聚乙烯糖醇 (PEG) 星与聚乙烯乳酸 (PLLA).
- 合成含有propargyl的ABA交叉连接剂与多D乳酸 (PDLA).
- 在脱离离子水中通过立体复合和稳定制造HMP的微流体制造
- 使用广角X射线散射 (WAXS) 和差分扫描热量计 (DSC) 的表征.
- 通过 thiol-yne 点击化学功能化.
主要成果:
- 通过微流体制造具有控制直径 (33.7105.7μm) 的明确的HMP.
- WAXS证实了立体复杂的多乳酸 (PLA) 的形成.
- DSC验证了具有特征结晶和点的立体复合.
- 在组装前或组装后使用thio-yne点击化学成功实现功能化.
结论:
- 立体复杂化为HMP制造提供了可行的非共价交叉链路策略.
- 开发的微流体方法可以精确控制HMP的大小.
- 在组织工程和药物输送中实现了先进的应用.
更多相关视频
08:17An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
Published on: July 18, 2018
7.1K
09:34Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
Published on: June 16, 2022
3.1K
相关概念视频
Solution Formation
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective solubility...
This selective solubility...
Two Components: Liquid–Liquid Systems
A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...
Surface Tension of Fluid
Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies with...
Surface tension varies with...
Couette Flow
Couette flow represents the flow of fluid between two parallel plates, with one plate fixed and the other moving with a constant velocity. This configuration allows for a simplified analysis using the Navier-Stokes equations, which govern fluid motion under conditions of viscosity and incompressibility. For Couette flow, the assumptions include a steady, laminar, incompressible flow with a zero-pressure gradient in the flow direction. This flow type is beneficial for understanding shear-driven...
The Buckingham Pi Theorem
The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.
Dimensionless Groups in Fluid Mechanics
Dimensionless groups in fluid mechanics provide simplified ratios that help analyze fluid behavior without relying on specific units. The Reynolds number (Re), which represents the ratio of inertial to viscous forces, distinguishes between laminar and turbulent flows, making it essential in the design of pipelines and aerodynamic surfaces. The Froude number (Fr), the ratio of inertial to gravitational forces, is particularly useful in predicting wave formation and hydraulic jumps in...
