面膜中的微塑料会损害精子的运动性.
Ziyi Lin1, Zijie Li2, Shuqin Ji2
1The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; University of Chinese Academy of Sciences, Beijing, China.
Marine pollution bulletin
|May 15, 2024
概括
COVID-19 面罩会造成微塑料污染. 接触这些微塑料会损害小鼠的精子运动,这表明哺乳动物的生殖健康存在潜在风险,并强调需要更好的废物管理.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖生物学 生殖生物学
背景情况:
- 随着COVID-19的流行,人们越来越多地使用一次性个人防护设备 (PPE),特别是面罩.
- 这导致了海洋和沿海环境的大量塑料污染.
- 从面具 (面具MP) 中获得的微塑料对包括人类在内的各种生物构成潜在风险.
研究的目的:
- 在哺乳动物模型中研究面罩中的微塑料的生殖毒性.
- 评估口服暴露于口罩MP对男性生殖参数和丸功能的影响.
主要方法:
- 一个小鼠模型被用于口服暴露,以掩盖MP的剂量为0.1和1毫克/天,持续21天.
- 分析了精子运动参数 (包括曲线速度和线性) 和精子计数.
- 进行了丸转录基因分析,以确定受影响的生物通路.
主要成果:
- 口服暴露于口罩MP并没有改变动物的运动,总重量或精子数量.
- 面膜MP暴露损害了精子的运动性,增加了曲线速度 (VCL).
- 高剂量暴露显著降低了精子线性 (LIN),丸转录学揭示了精子生成,氧化应激,炎症,新陈代谢和能量生产中的扰乱途径.
结论:
- 面膜中的微塑料会对哺乳动物的生殖能力产生不利影响,特别是精子运动.
- 这些发现凸显了与口罩MP污染相关的生态和健康问题.
- 需要改进塑料废物管理策略和开发环保替代品.
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