行为和自我报告的冲动性,大脑结构和中儿童时期遗传影响之间的关联
Jodi M Gilman1, Jasmeen Kaur2, Brenden Tervo-Clemmens3
1Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Developmental cognitive neuroscience
|May 15, 2024
概括
儿童的冲动性与前额和部区域的皮质区域较小有很弱的联系. 外化行为的遗传风险也与大脑结构和冲动性测量有明显的关联.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 行为遗传学 行为遗传学
背景情况:
- 冲动性在整个童年和青春期发展,受大脑成熟的影响.
- 连接儿童冲动性,大脑结构和遗传因素的大规模研究是有限的.
- 了解这些关系对于确定发育轨迹和潜在干预措施至关重要.
研究的目的:
- 为了研究冲动性,大脑结构 (皮层厚度,体积和区域) 和大量儿童中的遗传易感性之间的关联.
- 探索外部化行为的遗传风险与与冲动性相关的大脑结构之间的相互作用.
主要方法:
- 利用了来自ABCD研究的9112名儿童 (9-10岁) 的数据.
- 使用UPPS-P冲动行为尺度评估冲动性,并推迟折扣任务.
- 分析了大脑结构 (皮层厚度,体积,面积) 和外化行为的多基因分数 (PGS_EXT).
主要成果:
- 较高的冲动性得分 (UPPS-P,延迟折扣) 与前额和部区域的皮质区域 (CA) 较小有关.
- 在冲动性测量和皮质体积 (CV) 或皮质厚度 (CT) 之间没有发现显著的关联.
- 较高的PGS_EXT与UPPS-P得分增加以及前额和部区域较小的CA和CV的独特模式相关,突出显示了复杂的遗传-大脑-行为相互作用.
结论:
- 皮层区域 (CA) 显示出与冲动性测量和多基因风险的显著但微弱的关联,用于儿童的外部化行为,通过不同的区域模式发挥作用.
- 这些发现强调了遗传倾向,大脑结构和冲动性发展之间的复杂相互作用.
- 需要长度研究来追踪这些关联到青春期,并检查与功能性结果 (如物质使用和精神病理学) 的联系.
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