患有急性淋巴细胞白血病的儿童在步行过程中关节运动的改变,怀疑患有外围单元神经病变. 一个横截面研究
José Luis Alaniz-Arcos1, Xochiquetzalli Tejeda Castellanos1, Carlos Maximiliano Sánchez Medina1
1Physiotherapy Research Unit, Faculty of Medicine, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico.
Clinical biomechanics (Bristol, Avon)
|May 15, 2024
概括
患有急性淋巴细胞白血病 (ALL) 的儿童表现出改变的步态,包括速度减慢和步伐缩短,可能是由于化疗诱导的外周神经病变. 脚运动分析显示,与健康同龄人相比,有显著差异.
科学领域:
- 生物机械分析分析
- 儿科瘤学 儿科瘤学
- 神经学 神经学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 影响了步行时的脚运动.
- 患有急性淋巴细胞白血病 (ALL) 的儿童可能会出现CIPN.
- 了解这些儿童的步态变化对于监测和管理至关重要.
研究的目的:
- 描述 ALL 的学童在步行过程中的时空参数和脚运动.
- 在儿科ALL患者中发现暗示外围神经病变的步态变化.
- 将ALL患者的步态参数与规范数据进行比较.
主要方法:
- 使用Kinovea®软件分析步行过程中的时空和运动脚参数.
- 计算的步态参数包括节奏,步长,步态速度和脚脚下曲.
- 将获得的参数与立体光学测量系统的参考值进行比较.
主要成果:
- 评估了25名患有ALL的学童 (平均年龄为88个月).
- 在ALL患者中观察到明显较低的节奏,步长和步行速度 (p < 0.001).
- 在初始摆动过程中,脚足部曲在ALL患者中明显较低 (p < 0.05).
结论:
- 在患有ALL的学童中发现了显著的时空和运动步态变化.
- 研究结果表明,由于儿科ALL的外周神经病变,关节肌肉功能障碍可能存在.
- 需要进一步验证Kinovea®软件的准确性,以诊断ALL患者的步态变化.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
764
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
764
Alterations in Muscle Tone ll
27
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
27


