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Updated: Jun 26, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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发现二衍生物作为BRD4 (BD1) 选择性抑制剂

Xue-Peng Qiao1, Xue-Ting Wang1, Shuai Wang1

  • 1School of Pharmacy & Collaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou 730000, China.

Bioorganic & medicinal chemistry
|May 15, 2024
PubMed
概括

研究人员开发了新型的英多尔-2-衍生物,作为odomain蛋白4 (BRD4) BD1.1.的选择性抑制剂. 化合物21r具有强大的抗瘤活性,具有低毒性,具有治疗白血病的潜力.

关键词:
这是一种抗瘤药物.在BD1-选择性.这就是BRD4D.印度醇-2-单一的存在.抑制剂是一种抑制剂.

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