整个脊柱横向肌痛炎在神经肌痛炎光学谱系障碍中
Masoud Etemadifar1, Soulmaz Mousavi2, Mehri Salari3
1Department of Neurosurgery, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Multiple sclerosis and related disorders
|May 15, 2024
概括
整个脊髓横向肌痛炎 (TM) 是神经肌痛炎光谱障碍 (NMOSD) 的罕见并发症. 这种严重的TM形式与NMOSD患者的更糟糕的疾病结果和更高的残疾分数有关.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经炎症是一种神经炎症.
背景情况:
- 神经omyelitis光学谱系障碍 (NMOSD) 经常针对脊髓.
- NMOSD很少引起广泛的脊髓损伤,这种情况没有得到充分记录.
研究的目的:
- 描述NMOSD中罕见发生的全脊椎横向肌痛炎 (TM).
- 调查全脊椎TM的NMOSD的临床和放射性特征.
主要方法:
- 174名NMOSD患者的病历和MRI扫描的回顾性审查 (2011年1月 - 2023年1月).
- 识别患有全脊椎TM的患者.
- 对人口统计数据,临床投诉和抗体状态 (AQP4,MOG IgG) 的分析.
主要成果:
- 在5名患有NMOSD的患者中 (2,9%) 确定了整个脊柱TM.
- 所有患者的MOG IgG检测结果均为阴性;3人对AQP4抗体呈阳性.
- 下肢疲软是最常见的症状;患者的EDSS得分更高.
结论:
- 整体脊柱TM是一种罕见但严重的NMOSD表现.
- 这种情况与疾病严重程度增加和预后较差有关.
- 抗AQP4抗体在广泛性脊髓炎中的特定作用需要进一步研究.
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