相关实验视频
Updated: Jun 26, 2025

08:58
Artificial Intelligence Approaches to Assessing Primary Cilia
Published on: May 1, 2021
3.5K
超结构差异会影响视觉皮层的细胞类间的状和外部暴露
Carolyn M Ott1, Russel Torres2, Tung-Sheng Kuan3
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Current biology : CB
|May 15, 2024
概括
脑细胞,包括神经元和质细胞,具有具有不同结构和位置的初级乳毛. 这些乳毛在细胞类型之间存在差异,影响它们的功能和与大脑中的突触相互作用.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 显微镜的使用方法
背景情况:
- 初级毛是参与信号转导的细胞表面延伸.
- 由于复杂的神经环境,研究大脑乳毛是具有挑战性的.
研究的目的:
- 分析小鼠视觉皮层中初级眼的频率,结构,形状和位置.
- 为了比较神经元和质的特征,以及它们与突触的关系.
主要方法:
- 大脑组织体积的高分辨率传输电子显微镜.
- 激发性/抑制性神经元,星体细胞,寡干细胞前体细胞 (OPC),寡干细胞和微细胞中的毛的超结构分析.
主要成果:
- 在神经元,星球细胞和OPC中发现了初级乳毛,但不是在寡头细胞或微细胞上.
- 在神经元和神经之间,在底和微管组织中存在显著的超结构差异.
- 纤毛靠近突触主要是由于随机分布和纤毛长度,而不是突触活动的直接调节.
- 细胞特异性乳毛结构影响它们的位置,形状和与周围的神经过程和突触的相互作用.
结论:
- 神经元和质毛表现出明显的超结构特征和与突触的空间关系.
- 这些差异表明细胞类型特定的机制,用于脑中的毛形成和功能.
- 大脑中的初级毛囊在结构上有多样性,并与当地的神经环境相互作用.
相关概念视频
Anatomy of the Eyeball
7.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.1K
Microtubules in Signaling
1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
Vision
53.2K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.2K
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Mechanism of Ciliary Motion
3.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.7K
Visual System
574
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
574

