癌症免疫疗法对心血管有毒性的免疫疗法
Nicolas L Palaskas1, Hyeon-Ju Ali1, Efstratios Koutroumpakis1
1University of Texas MD Anderson Cancer Center, Houston, TX, USA.
免疫检查点抑制剂 (ICI) 和CAR-T疗法可以导致严重的心血管副作用,如心肌炎和心力衰竭. 本综述详细介绍了这些影响心脏的免疫相关不良事件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 癌症疗法越来越多地利用基于免疫的治疗方法,包括免疫检查点抑制剂 (ICI) 和仿真抗原受体T细胞疗法 (CAR-T).
- 这些先进疗法虽然有效,但与影响各种器官系统,特别是心血管系统的免疫相关不良事件 (irAEs) 有关.
研究的目的:
- 审查与ICI和CAR-T疗法相关的心血管不良影响的当前理解.
- 要突出这些免疫疗法产生的心脏并发症的范围.
主要方法:
- 对调查ICI和CAR-T心血管并发症的研究进行文献综述.
- 综合报告的不良事件,包括心肌炎,心膜炎,心律失常和心力衰竭.
主要成果:
- ICI与心肌炎,心周炎,血管炎,血栓栓塞和加速动脉样硬化有关.
- 卡特-T疗法可能导致细胞因子释放综合征,导致心律失常,心肌梗塞和心力衰竭.
结论:
- 心血管不良影响是ICI和CAR-T治疗的一个重要问题.
- 在现代癌症护理中,对心脏irrAEs的认识和监测对于患者管理至关重要.
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