风湿性关节炎患者的门诊血压:与免疫激活的关联
Michelle J Ormseth1, Annette M Oeser2, Cecilia P Chung3
1M.J. Ormseth, MD, MSCI, Department of Medicine, Vanderbilt University Medical Center, and Tennessee Valley Healthcare System, U.S. Department of Veterans Affairs, Nashville, Tennessee; Michelle.ormseth@vumc.org.
The Journal of rheumatology
|May 15, 2024
概括
风湿性关节炎 (RA) 患者的24小时和夜间血压 (BP) 比对照人高,与免疫活性有关. 这表明RA患者可能有未诊断的高血压需要监测.
科学领域:
- 心血管健康 心血管健康
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 高血压是一个重要的心血管风险因素.
- 类风湿性关节炎 (RA) 与高血压患病率的增加有关.
- 免疫激活可能导致RA的高血压.
研究的目的:
- 为了比较RA患者的24小时门诊血压 (BP) 与对照人群.
- 调查高血压与RA中的免疫激活之间的关联.
主要方法:
- 一项涉及46名RA患者和23名对照者的横截面研究.
- 门诊血压监测 (24小时,白天,夜间).
- 测量了等离子体炎症媒介;通过曼-惠特尼U测试评估了血压差异;斯皮尔曼的相关性.
主要成果:
- 与对照组相比,RA患者的24小时,白天和夜间缩血压 (SBP) 中位数较高.
- 晚间透静血压 (DBP) 也在RA患者中较高.
- 在RA患者中观察到夜间血压下降的减少,与炎症介质有很强的相关性.
结论:
- 门诊BP,特别是夜间SBP在RA患者中升高,尽管类似的办公室BP.
- 在RA中血压升高与全身炎症显著相关.
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