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随机试验比较复杂的腿骨关节损伤中避开支架的策略与支架优先策略

Tim Wittig¹, Andrej Schmidt², Torsten Fuß³

¹Division of Angiology, Department of Internal Medicine, Neurology and Dermatology, University Hospital Leipzig, Leipzig, Germany; Helmholtz Institute for Metabolic, Obesity and Vascular Research of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

JACC. Cardiovascular interventions

|May 15, 2024

概括

这项研究比较了复杂的股骨干预的避开支架与支架优先策略,发现了类似的12个月穿透性和安全性结果. 这两种方法都强调用药物释放装置进行病变准备,显示出对治疗完全闭塞的希望.

科学领域:

血管外科血管外科
干预心脏病学干预心脏病学
血管内干预血管内干预

背景情况:

有限的比较数据存在于复杂的骨关节疾病的内血管再血管化策略.
在这些干预中,最佳的病变准备和药物释放技术的使用至关重要.

研究的目的:

为了比较一个避开支架 (SA) 策略与支架优先 (SP) 策略对复杂的股骨损伤.
用药物泄露技术评估这些策略的有效性和安全性.

主要方法:

一项前性,多中心的试点研究随机选择了120名患有复杂的股骨损伤的患者 (Rutherford 2-4) 接受SA或SP内血管治疗.
两只手臂都使用了涂有帕克利塔塞尔的气球或帕克利塔塞尔释放的支架,在操作员的判断下进行病变准备.

主要成果:

12个月的初级通透率是可比的:78.2% (SA) 和78.6% (SP) (P=1.0).
从重大不良事件的自由度很高和相似:93.1% (SA) 与94.9% (SP) (P=0.717) 相比.
伤害制备在SA组中更频繁 (71.7%对51.7%,P=0.038),临时支架率为48.3%.

结论:

避免支架和支架优先的内血管策略,专注于用药物释放装置准备病变,显示出有前途的有效性和安全性.
这些策略在12个月后对复杂的股骨关节手术,包括高比例全遮手术,显得有效.

关键词:

帕克利塔克塞尔排泄装置穿透性穿透性穿透性周围动脉疾病是什么静止性静止症是一种静止症.船舶准备工作船舶准备工作

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