[手术前免疫疗法的外科和病理后果在瘤泌尿病学]
Youssef Lyoubi1, Sarah Bellal2, Souhil Lebdai1
1Service d'urologie, CHU d'Angers, université d'Angers, Angers, France.
Bulletin du cancer
|May 15, 2024
概括
接受免疫治疗的患者的手术是可行的,没有增加的手术困难或并发症. 病理学分析显示,手术样本中没有与手术前免疫疗法相关的特定变化.
科学领域:
- 泌尿外科瘤学 泌尿外科瘤学
- 手术瘤学手术瘤学
- 免疫治疗是一种免疫疗法.
背景情况:
- 接受免疫治疗的患者可能需要针对各种泌尿病状况进行手术.
- 指示包括细胞还原性切除术,囊切除术和转移移除术.
- 评估这些患者的手术可行性和组织学变化至关重要.
研究的目的:
- 评估之前用全身免疫疗法治疗的患者手术的可行性.
- 描述免疫治疗患者手术样本中的组织学修饰.
- 为了比较免疫疗法治疗和非免疫疗法治疗的手术患者之间的术后结果和炎症透.
主要方法:
- 在2018年2月至2022年6月期间,对50名接受尿道癌手术的患者进行了回顾性单心研究.
- 以往接受系统免疫治疗的患者与没有免疫治疗的对照组进行比较.
- 对外科手术后并发症,出血量和外瘤炎症透的分析.
主要成果:
- 两组之间年龄或性别分布没有显著差异.
- 周围手术 (20%对16%) 和术后 (48%对56%) 并发症的比较率.
- 类似的平均出血量和相同的周围瘤炎症透率 (96%).
结论:
- 术前免疫疗法不会增加泌尿癌患者的手术困难或术后并发症.
- 手术样本的组织学检查显示,没有可归因于手术前免疫治疗的独特特征.
- 对于接受免疫治疗的患者来说,手术仍然是一个可行的选择.
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