美国成年人中氧化平衡得分与耐性高血压和动脉硬之间的关联:基于人口的研究
Rujie Zheng1, Wenjuan Song1, Che Wang2
1The First Central Clinical School, Tianjin Medical University, Tianjin, China.
概括
保持健康的氧化平衡得分 (OBS) 与抗性高血压 (RHT) 的风险降低以及高血压成年人的动脉硬性降低有关. 这凸显了OBS对心血管健康的重要性.
科学领域:
- 心血管健康 心血管健康
- 高血压管理 高血压管理
- 代谢健康 代谢健康
背景情况:
- 之前的研究将氧化平衡得分 (OBS) 与高血压 (HTN) 联系起来.
- OBS与抗性高血压 (RHT) 之间的关联尚未得到充分证实.
- 在高血压患者中,OBS与动脉硬之间的关系需要进一步研究.
研究的目的:
- 在高血压成年人中调查OBS和RHT之间的关联.
- 在高血压患者中探索OBS和动脉硬之间的关系.
- 检查OBS和主要不良心血管事件 (MACE) 之间的关联.
主要方法:
- 从NHANES (2001-2018) 分析了15910名患有高血压的美国成年人.
- 计算和OBS (整体,饮食和生活方式) 的四分之一分类.
- 使用了权重回归,分层分析和受限立方线 (RCS) 模型.
主要成果:
- 较高的OBS四分位数显示出与RHT的一致的反向关联 (p < 0.05).
- 最高的OBS四分位数与最低的OBS四分位数相比,与RHT风险降低30.8%有关.
- OBS与动脉硬性降低显著相关 (ePWV:β = -0.014,p = 0.032).
- 在OBS和RHT,MACE,心血管死亡和非致命性心脏病发作之间观察到非线性关联.
结论:
- 升高的OBS与美国成人高血压的RHT风险有负面关联.
- 在高血压患者中,较高的OBS与降低动脉硬度相关.
- 导致OBS的生活方式因素似乎对管理RHT特别重要.
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