顺序便标记检查的有效性,以评估胃肠道炎症在固体食品蛋白质诱导的肠球炎综合征
Masumi Nagata1, Eisuke Inage2, Hiromichi Yamada2
1Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Pediatrics, Tobu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, Tokyo, Japan.
概括
便中的血红蛋白,乳酸和calprotectin水平有效地诊断固体食物蛋白诱导肠球炎综合征 (固体-FPIES) 并评估胃肠道炎症. 这些标记物为管理这种非IgE介导的过敏状况提供了宝贵的见解.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 固体食物蛋白诱导肠球炎综合征 (Solid-FPIES) 是一种非IgE介导的过敏,导致延迟的胃肠道症状.
- 口服食品挑战 (OFC) 对轻度固体FPIES病例可能没有结论.
- 由于目前的选择有限,需要新的诊断标记物.
研究的目的:
- 评估便中的血红蛋白 (FHb),乳酸铁素 (FLf) 和calprotectin (FCp) 作为固体FPIES的诊断标记.
- 评估这些便标记物在量化胃肠道炎症随时间推移的有用性.
主要方法:
- 一项观察性研究涉及40名患者和42次固体FPIES,对照和缓解.
- 在抗原暴露后7天内,分析了FHb,FLf和FCp的便样本.
- 与基线值相对应的标记器比率的时间分析.
主要成果:
- 与对照组相比,FPIES患者的FHb,FLf和FCp峰值比率显著更高 (p <0.01).
- 在FPIES与对照中的中位峰标记比率:FHb (3.25与1.08),FLf (9.09与1.29),FCp (9.79与1.49).
- 接收器操作特征分析证实了固体FPIES中所有便标记物的高诊断性能.
结论:
- 顺序便标记分析对于诊断固体FPIES非常有价值.
- 这些标志物有效评估固体FPIES中胃肠道炎症的程度.
- 便标志物显示出作为固体FPIES管理的可靠指标的希望.
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