营养药混合物预测通过微生物群重塑改善细胞因子和生活质量的增强健康:巴西双盲随机试验
Aline Boveto Santamarina1,2, Jéssica Alves de Freitas1,2, Lucas Augusto Moyses Franco3
1Laboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, 01246903, Brazil.
Scientific reports
|May 15, 2024
概括
两种营养药物改善了肥胖成年人的肠道微生物群和代谢健康. 配合西利玛林 (乳) 的配方显示对肠道细菌,睡眠和炎症标志物有增强的益处.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 营养学科学 营养学科学
背景情况:
- 对治疗代谢疾病和调节肠道微生物群的营养药品越来越感兴趣.
- 慢性压力,肠道失调和炎症与睡眠障碍和降低生活质量有关.
- 超重和肥胖与代谢失调和健康风险增加有关.
研究的目的:
- 评估两种营养药配方 (NSupple和NSupple_Silybum) 对它们对肠道微生物群,代谢参数和生活质量的影响.
- 评估益生菌,矿物质和西利马林对超重/肥胖个体的影响.
- 研究肠道微生物群变化与临床改善之间的关系.
主要方法:
- 与超重/肥胖志愿者进行了180天的干预研究.
- 两种营养药配方的使用:NSupple (益生菌,矿物质) 和NSupple_Silybum (益生菌,矿物质,西利马林).
- 评估便肠道微生物群 (16S rRNA测序),细胞因子表达,人体测量,生活质量,睡眠模式,以及基线和180天的代谢/激素参数.
主要成果:
- 这两种配方都调节了肠道微生物群的组成,分别是类,属和物种.
- NSupple_Silybum组显示出巴克特罗伊德斯系,巴克特罗伊德斯和普雷沃特拉属的显著正调节.
- 肠道微生物群的改善与改善睡眠质量,感知生活质量,减少炎症 (细胞因子) 和更好的人类测量相关.
结论:
- 营养药混合物对心脏代谢和炎症标志物产生积极影响.
- NSupple_Silybum在调节微生物群组成和改善代谢失调方面表现出显著的潜力.
- 研究结果表明,营养药物干预可以成为管理代谢健康和改善幸福感的宝贵工具.
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