作为良性前列腺增生症单体治疗的α阻塞剂的比较疗效和安全性:系统性审查和网络元分析
Beema T Yoosuf1, Abhilash Kumar Panda1, Muhammed Favas Kt1
1Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab, India.
Scientific reports
|May 15, 2024
概括
阿尔法阻断剂有效地治疗良性前列腺增生症 (BPH) 症状,如IPSS. 坦苏洛辛,纳夫托皮迪尔和西洛多辛比安慰剂显著改善症状,坦苏洛辛在改善症状和流速方面排名最高.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 证据综合 证据综合
背景情况:
- 阿尔法阻断剂是良性前列腺增生症 (BPH) 的第一线治疗方法.
- 在阿尔法抑制剂之间直接比较的疗效和安全性数据是有限的.
- 网络元分析 (NMA) 对于合成来自多个随机对照试验 (RCT) 的证据至关重要.
研究的目的:
- 评估各种阿尔法阻断剂在BPH管理中的比较疗效和安全性.
- 根据症状改善,尿流和生活质量来确定最佳的α阻塞剂.
- 评估与不同阿尔法抑制剂相关的治疗出现不良事件 (TEAE).
主要方法:
- 进行了随机对照试验 (RCT) 的综合网络元分析 (NMA).
- 搜索包括到2023年8月的PubMed,Embase,Ovid MEDLINE和科克兰图书馆.
- 主要结局:国际前列腺症状评分 (IPSS),最大流量 (Qmax),生活质量 (QoL),空气后残留体积 (PVR);二次结局:TEAEs.
主要成果:
- 与安慰剂相比,tamsulosin 0.4 mg,naftopidil 50 mg和silodosin 8 mg显著改善了IPSS. 这两种药物可以帮助患者获得更好的治疗效果.
- 坦素0.4毫克证明了改善IPSS,PVR和Qmax的可能性最高.
- 多克萨佐辛8毫克显示了改善QOL的最高概率;西洛多辛报告了大量的TEAE.
结论:
- 阿尔法阻断剂对于减少BPH症状 (IPSS) 是有效的,并且通常是安全的.
- 坦素0.4毫克是症状和流动改善的领先选择.
- 需要进一步进行大规模的长期研究,以完善阿尔法阻断剂治疗的结果估计.
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